Vol. 9 No. 1 (2026)
Open Access
Peer Reviewed

RADIOLOGICAL CHARACTERISTICS OF 3D-PRINTED PETG AND TPU AT DIFFERENT INFILL PERCENTAGES FOR BREAST CANCER RADIOTHERAPY BOLUS

Authors

Luthfia Aqila Abrar , Sri Herwiningsih , Johan Andoyo Effendi Noor , Faisal Ahlan Rizaldi , Fatimah Kunti Hentihu

DOI:

10.29303/ipr.v9i1.531

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Received: Jul 12, 2025
Accepted: Oct 31, 2025
Published: Nov 13, 2025

Abstract

Skin-sparing effect causes the radiation dose at a certain depth to be higher than at the skin surface. A tissue-equivalent material namely bolus is required to increase the radiation dose to the skin surface. Conventional bolus is widely used, it poorly conforms to irregular surface, leading to air gaps and compromising dose distribution accuracy. The three-dimensional (3D) printing technology enables the fabrication of 3D-printed boluses to minimize the air gap in conventional bolus applications. In addition, 3D printing is allowed to modify its infill percentage and infill patterns, minimizing both printing time and material usage but resulting in different radiological and dosimetric characteristics. Therefore, it is crucial to evaluate the radiological characteristics of 3D-printed bolus before its application in breast cancer radiotherapy. In this study, the radiological characteristics of 3D-printed Polyethylene Terephthalate Glycol (PETG) and Thermoplastic Polyurethane (TPU) boluses at different infill percentages have been evaluated. This research utilized eight plate-shaped 3D-printed bolus samples with dimensions of 12 cm × 12 cm × 1 cm, at the infill percentages of 20%, 40%, 60%, and 80%. Each bolus sample was scanned using a CT-Simulator to determine its Hounsfield Unit (HU) values and linear attenuation coefficients. The obtained HU values were compared with the HU values of human tissues. The results indicate that both 3D-printed PETG and TPU boluses demonstrate similar equivalency to adipose tissue. Consequently, based on radiological evaluation, PETG and TPU materials are suitable for use in fabricating 3D-printed bolus for breast cancer radiotherapy application.

 

Keywords:

3D-printed bolus infill percentage bolus tissue equivalency materials Hounsfield Unit analysis linear attenuation coefficient radiotheraphy dose optimization

References

[1] E. . Podgorsak, Radiation Oncology Physics: A Handbook for Teacher and Student. Vienna, 2005.

[2] A. P. Hariyanto, F. U. Mariyam, L. Almira, E. Endarko, and B. H. Suhartono, “Fabrication and characterization of bolus material using propylene glycol for radiation therapy,” Iran. J. Med. Phys., vol. 17, no. 3, pp. 161–169, 2020.

[3] A. Jreije et al., “Development of patient specific conformal 3d-printed devices for dose verification in radiotherapy,” Appl. Sci., vol. 11, no. 18, pp. 1–12, 2021.

[4] S. Y. Astuti, H. Sutanto, E. Hidayanto, G. W. Jaya, A. S. Supratman, and G. P. Saraswati, “Characteristics of Bolus Using Silicone Rubber with Silica Composites for Electron Beam Radiotherapy,” J. Phys. Its Appl., vol. 1, no. 1, pp. 24–27, 2018.

[5] J. A. Diaz-Merchan, S. A. Martinez-Ovalle, and H. R. Vega-Carrillo, “Characterization of a novel material to be used as bolus in radiotherapy with electrons,” Appl. Radiat. Isot., vol. 183, 2022.

[6] E. Endarko, S. Aisyah, C. C. C. Carina, T. Nazara, G. Sekartaji, and A. Nainggolan, “Evaluation of dosimetric properties of handmade bolus for megavoltage electron and photon radiation therapy,” J. Biomed. Phys. Eng., vol. 11, no. 6, pp. 735–746, 2021.

[7] D. Lobo et al., “Influence of air gap under bolus in the dosimetry of a clinical 6 mv photon beam,” J. Med. Phys., vol. 45, no. 3, pp. 175–181, 2020.

[8] S. N. Rismawati, J. A. E. Noor, Y. Yueniwati, and F. K. Hentihu, “Impact of In-House Bolus Thickness on The Percentage of Surface Dose for 10 and 12 MeV Electron Beams,” J. Penelit. Pendidik. IPA, vol. 8, no. 6, pp. 2833–2839, 2022.

[9] L. Dilson et al., “Estimation of Surface Dose in the Presence of Unwanted Air Gaps under the Bolus in Postmastectomy Radiation Therapy: A Phantom Dosimetric Study,” Asian Pacific journal of cancer prevention : APJCP, vol. 23, no. 9. pp. 2973–2981, 2022.

[10] Y. Lu, J. Song, X. Yao, M. An, Q. Shi, and X. Huang, “3D Printing Polymer-based Bolus Used for Radiotherapy,” Int. J. Bioprinting, vol. 7, no. 4, pp. 1–16, 2021.

[11] G. Gomez et al., “A three-dimensional printed customized bolus: adapting to the shape of the outer ear,” Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, vol. 26, no. 2. pp. 211–217, 2021.

[12] A. Yuliandari, S. Oktamuliani, Harmadi, and F. Diyona, “Dosimetric Characterization of 3D Printed Bolus with Polylactic Acid (PLA) in Breast Cancer External Beam Radiotherapy,” Iran. J. Med. Phys., vol. 21, no. 3, pp. 211–216, 2024.

[13] X. Wang et al., “3D-printed bolus ensures the precise postmastectomy chest wall radiation therapy for breast cancer,” Front. Oncol., vol. 12, 2022.

[14] A. C. Ciobanu, L. C. Petcu, F. Járai-Szabó, and Z. Bálint, “Exploring the impact of filament density on the responsiveness of 3D-Printed bolus materials for high-energy photon radiotherapy,” Phys. Medica, vol. 127, 2024.

[15] J. A. Diaz-Merchan, C. Español-Castro, S. A. Martinez-Ovalle, and H. R. Vega-Carrillo, “Bolus 3D printing for radiotherapy with conventional PLA, ABS and TPU filaments: Theoretical-experimental study,” Applied radiation and isotopes, vol. 199. 2023.

[16] S. G. Gugliandolo et al., “3D‑printed boluses for radiotherapy infuence of geometrical and printing parameters on dosimetric characterization and air gap evaluation,” Radiol. Phys. Technol., vol. 17, pp. 347–359, 2024.

[17] K. H. Jung, D. H. Han, K. Y. Lee, J. O. Kim, W. S. Ahn, and C. H. Baek, “Evaluating the performance of thermoplastic 3D bolus used in radiation therapy,” Appl. Radiat. Isot., vol. 209, 2024.

[18] C. Zhang, W. Lewin, A. Cullen, D. Thommen, and R. Hill, “Evaluation of 3D-printed bolus for radiotherapy using megavoltage X-ray beams,” Radiol. Phys. Technol., vol. 16, no. 3, pp. 414–421, 2023.

[19] E. Dąbrowska-Szewczyk et al., “Low-density 3D-printed boluses with honeycomb infill 3D-printed boluses in radiotherapy,” Phys. Medica, vol. 110, 2023.

[20] D. D. Pereira et al., “Validation of polylactic acid polymer as soft tissue substitutive in radiotherapy,” Radiat. Phys. Chem., vol. 189, p. 109726, 2021, Available: https://www.sciencedirect.com/science/article/pii/S0969806X21003765

[21] F. Biltekin, G. Yazici, and G. Ozyigit, “Characterization of 3D-printed bolus produced at different printing parameters,” Med. Dosim., vol. 46, no. 2, pp. 157–163, 2021.

[22] M. Bento et al., “Characterisation of 3D printable thermoplastics to be used as tissue-equivalent materials in photon and proton beam radiotherapy end-to-end quality assurance devices,” Biomed. Phys. Eng. express, vol. 10, 2024.

[23] SUNLU, “Technical Datasheet of TPU,” 2024. Available: https://www.3dsunlu.com/pages/materials. [Accessed: Feb. 02, 2025]

[24] eSun Industrial Co. Ltd, “PETG,” 2025. Available: https://www.esun3d.com/petg-product/?gad_source=1&gad_campaignid=17538533238&gbraid=0AAAAABIkeXn9kWfERGN-_GZVgKquS9uHd&gclid=Cj0KCQjw-NfDBhDyARIsAD-ILeA_blyeWeMK5uNiHNUN-1d29cxGYAyOA_4SxgQTmh8ifomxrMWoxOMaAhVLEALw_wcB.

[25] D. R. Dance, S. Chistofides, A. D. A. Maidment, I. D. McLean, and K. H. Ng, Diagnostic Radiology Physics: A Handbook for Teachers and Students. Vienna: IAEA, 2014.

[26] A. P. Hariyanto, K. H. Christianti, A. Rubiyanto, N. Nasori, M. Haekal, and E. Endarko, “The Effect of Pattern and Infill Percentage in 3D Printer for Phantom Radiation Applications,” J. ILMU DASAR, vol. 23, no. 2, p. 87, 2022.

[27] J. Madamesila, P. McGeachy, J. E. Villarreal Barajas, and R. Khan, “Characterizing 3D printing in the fabrication of variable density phantoms for quality assurance of radiotherapy,” Phys. Medica, vol. 32, no. 1, pp. 242–247, 2016.

[28] eSun Industrial Co. Ltd, “Data Sheet PETG,” 2021. Available: www.esun3d.net.

[29] X. Ma, M. Buschmann, E. Unger, and P. Homolka, “Classification of X-Ray Attenuation Properties of Additive Manufacturing and 3D Printing Materials Using Computed Tomography From 70 to 140 kVp,” Front. Bioeng. Biotechnol., vol. 9, pp. 1–13, 2021.

Author Biographies

Luthfia Aqila Abrar, Physics Department, Faculty of Mathematics and Natural Science, University of Brawijaya

Sri Herwiningsih, Physics Department, Faculty of Mathematics and Natural Science, University of Brawijaya

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How to Cite

Abrar, L. A., Sri Herwiningsih, Johan Andoyo Effendi Noor, Faisal Ahlan Rizaldi, & Fatimah Kunti Hentihu. (2025). RADIOLOGICAL CHARACTERISTICS OF 3D-PRINTED PETG AND TPU AT DIFFERENT INFILL PERCENTAGES FOR BREAST CANCER RADIOTHERAPY BOLUS. Indonesian Physical Review, 9(1), 49–57. https://doi.org/10.29303/ipr.v9i1.531

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