MONTE CARLO ANALYSIS OF FETAL DOSE DISTRIBUTION IN PREGNANCY FOR DIFFERENT FETAL AGES, BEAM LOCATION, BEAM ENERGY, AND FIELD SIZES

Khusniatun  Nikmah; Muhammad Vitro  Ramadhan; Tony  Sumaryada; Muhammad Fahdillah  Rhani; Abd. Djamil  Husin; Sitti  Yani

doi:10.29303/ipr.v8i1.406

MONTE CARLO ANALYSIS OF FETAL DOSE DISTRIBUTION IN PREGNANCY FOR DIFFERENT FETAL AGES, BEAM LOCATION, BEAM ENERGY, AND FIELD SIZES

Authors

Khusniatun Nikmah , Muhammad Vitro Ramadhan , Tony Sumaryada , Muhammad Fahdillah Rhani , Abd. Djamil Husin , Sitti Yani

DOI:

10.29303/ipr.v8i1.406

Published:

2025-01-26

Issue:

Vol. 8 No. 1 (2025)

Keywords:

EGSnrc, fetal dose, Monte Carlo Method, pregnancy

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Nikmah, K. ., Ramadhan, M. V. ., Sumaryada, T. ., Rhani, M. F. ., Husin, A. D. ., & Yani, S. . (2025). MONTE CARLO ANALYSIS OF FETAL DOSE DISTRIBUTION IN PREGNANCY FOR DIFFERENT FETAL AGES, BEAM LOCATION, BEAM ENERGY, AND FIELD SIZES . Indonesian Physical Review, 8(1), 328–339. https://doi.org/10.29303/ipr.v8i1.406

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Abstract

Treatment with radiotherapy in pregnant women may occur due to some critical conditions. The dose given during the treatment process is not only received by the patient but can also be absorbed by the fetus which can affect its growth. Moreover, the radiation target is near the fetus such as the lung. This study aims to determine the dose distribution to the fetus with variations in fetal age (trimester 1, 2, and 3), beam energy, field size, and fetal distance to the target location (lung). The entire simulation utilized the Monte Carlo-based software EGSnrc-DOSXYZnrc which produced a 3-dimensional dose distribution on the virtual phantom. The simulated virtual phantom is a box with a size of 40×40×40 cm3 containing several materials, namely water, tissue, and lung. The size of the fetus is varied according to trimesters 1, 2, and 3. The beam is in the form of monoenergetic photons with energies of 3 MeV and 5 MeV emitted from above with a source to surface distance (SSD) of 48 cm. The field size was set at 5×5 cm2 and 8×8 cm2 on the phantom surface. The beam axis was located at a distance of 5 cm and 3 cm from the fetus. The results showed that the four variations performed affected the fetal dose, where the fetal dose increased considerably when the field size was enlarged and the beam axis was closer to the fetal position. The increase in fetal dose is also influenced by the increase in fetal age and beam energy. Meanwhile, the location of the beam below the lung causes an increased dose to the fetus due to the closer position of the beam to the fetus.

References

O. D. Asmara, E. D. Tenda, G. Singh, C. W. Pitoyo, C. M. Rumende, W. Rajabto, N. R. Ananda, I. Trisnawati, E. Budiyono, H.F Thahadian, E. C. Boerma, A. Faisal, D. Hutagaol, W. Soeharto, F. Radityamurti, E. Marfiani, P. Z. Romadhon, F. N. Kholis, H. Suryadinata, A. Y. Soeroto, S. A. Gondhowiardjo, W. H. Geffen, “Lung Cancer in Indonesia”, Journal of Thoracic Oncology, vol. 18, no. 9, pp. 1134 – 1145, June. 2023.

S. H. Bradley, M. P. T. Kennedy, R. D. Neal, “Recognising Lung Cancer in Primary Care”, Adv Ther, vol. 36, no. 1, pp. 19 – 30, 2019.

D. Palma, O Visser, F. J. Lagerwaard, J. Belderbos, B. J. Slotman, S. Senan, “Impact Of Introducing Stereotactic Lung Radiotherapy For Elderly Patients With Stage I Non-Small-Cell Lung Cancer: A Population-Based Time-Trend Analysis”, J Clin Oncol, vol. 28, no. 35, pp. 5153-9, Dec. 2010.

E. D. Brooks, B. Sun, L. Zhao, R. Komaki, Z. Liao, M. Jeter, “Stereotactic Ablative Radiation Therapy is Highly Safe and Effective for Elderly Patients with Early-stage Non-Small Cell Lung Cancer”, Int J Radiat Oncol Biol Phys, vol. 98, no. 4, pp. 900–907, Jul. 2017.

S. Senthi, F. J. Lagerwaard, C. J. Haasbeek, B. J. Slotman, S. Senan, “Patterns Of Disease Recurrence After Stereotactic Ablative Radiotherapy For Early Stage Non-Small-Cell Lung Cancer:A Retrospective Analysis”, Lancet Oncol, vol. 13, no. 8, pp. 802–9. Aug. 2012.

P. Iyengar, K. Westover, R. D. Timmerman, “Stereotactic Ablative Radiotherapy (SABR) For Non-Small Cell Lung Cancer”, Semin Respir Crit Care Med, vol. 34, no. 6, pp. 845–54, Dec. 2013.

K. Wang, J. E. Tepper, “Radiation Therapy-Associated Toxicity: Etiology, Management, And Prevention”. CA Cancer J Clin, vol. 71, no. 5, pp. 437–454, Jul. 2021.

S. Boussios, S. N. Han, R. Fruscio, M. J. Halaska, P. B. Ottevanger, F. A. Peccatori, L. Koubkova, N. Pavlidis, FAmant, “Lung Cancer in Pregnancy: Report of Nine Cases from An International Collaborative Study”, Lung Cancer, vol. 82, no. 3, pp. 499-505, 2013.

H. B. Kal, H. Struikmans. “Radiotherapy During Pregnancy: Fact and Fiction”, Lancet Oncol, vol. 6, no. 5, pp. 328-333, May. 2005.

D. Pereg, G. Koren, M. Lishner, “Cancer in pregnancy: Gaps, challenges and solutions”, Cancer Treatment Reviews, vol. 34, no. 4, pp. 302-312, Jun. 2008.

S. Y. Woo, L. M. Fuller, J. H. Cundiff, M. L. Bondy, F. B. Hagemeister, P. McLaughlin, W. S. Velasquez, F. Swan, M. A. Rodriguez, F. Cabanillas, P. K. Allen, R. J. Carpenter, “Radiotherapy During Pregnancy for Clinical Stages IA–IIA Hodgkin's Disease”, Int J Radiat Oncol Biol Phys, vol. 23, no. 2, pp. 407-412, 1992.

E. Angel, C. V. Wellnitz, M. M. Goodsitt, N. Yaghmai, J. J. DeMarco, C. H. Cagnon, J. W. Sayre, D. D. Cody, D. M. Stevens, A. N. Primak, C. H. McCollough, M. F. McNitt-Gray, “Radiation Dose to The Fetus for Pregnant Patients Undergoing Multidetector CT Imaging: Monte Carlo Simulations Estimating Fetal Dose for A Range of Gestational Age and Patient Size”, Radiology, vol. 249, no. 1, pp. 220-7, Oct. 2008.

M. Mazonakis, A. Tzedakis, J. Damilakis J, “Monte Carlo Simulation of Radiotherapy for Breast Cancer in Pregnant Patients: How to Reduce the Radiation Dose and Risks to Fetus”, Radiatation Protection Dosimetry, vol. 175, no. 1, pp. 10-16, Sep. 2016.

M. Aabid, S. Semghouli, B. Amaoui, A. Choukri. “Evaluation Of Fetal Dose During Pelvimetry CT Scan Procedure by Monte Carlo Using GATE”, Radiation Physics and Chemistry, vol. 210, pp. 111042, Sep. 2023.

R. Mohan, J. Antolak, “Monte Carlo Techniques Should Replace Analytical Methods for Estimating Dose Distributions in Radiotherapy Treatment Planning”, Med. Phys, vol. 28, no. 2, pp. 123-126, Feb. 2001.

I. F. Maulana, S. Yani, T. Sumaryada, M. F. Rhani, F. Haryanto, “Commissioning of Elekta Infinity™ 6 MV flattening filter-free using Monte Carlo simulation”, Radiation Physics and Chemistry, vol. 210, pp. 11101, Sep. 2023.

S. Yani, Y. A. Noviantoro, M. F. Rhani, T. Sumaryada, F. Haryanto, “Verification Of 3D-CRT Dose Distribution in Arccheck Phantom Using Monte Carlo Code”, Radiation Physics and Chemistry, vol. 210, pp. 111019, Sep. 2023.

M. S. Wyatt, L. F. Miller, "A comparison of Monte Carlo and model-based dose calculations in radiotherapy using MCNPTV", Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 562(2), pp. 1013-1016, 2006.

J. Park, C. Kung, "Monte Carlo Based Algorithms Are More Accurate for Dose Calculations in Radiotherapy", Biomedical Science and Engineering, vol. 2, no.2, pp. 40-41, 2014.

J. Wu, Y. Xie, Z. Ding, F. Li, L. Wang, "Monte Carlo study of TG-43 dosimetry parameters of GammaMed Plus high dose rate 192Ir brachytherapy source using TOPAS", J Appl Clin Med Phys, vol. 22, pp. 146-153, 2021.

L. Brualla, M. Rodriguez, J. Sempau, P. Andreo, “PENELOPE/PRIMO-Calculated Photon and Electron Spectra from Clinical Accelerators”, Radiat Oncol, vol. 14, no. 6, pp. 6, Jan. 2019.

Y. Benameur, M. Tahiri, M. Mkimel, R. E. Baydaoui, M. Najeh, S. Sahraoui, N. Benchekroun, M. Bougteb, B. E. Hariri, M. R. Mesradi, A. Hilali, E. M Saad, “Fetal Dose Estimation During Pregnancy Using Gate Monte Carlo Simulation: Application of Hodgkin’s Lymphoma Radiotherapy”, Radiation Protection Dosimetry, vol. 199, no. 7, pp. 581–587, May. 2023.

C. Geng, M. Moteabbed, J. Seco, Y. Gao, X, G. Xu, J. R. Méndez, B. Faddegon, H. Paganetti, “Dose Assessment for The Fetus Considering Scattered and Secondary Radiation from Photon and Proton Therapy When Treating a Brain Tumor Of The Mother”, Phy Med Biol, vol. 61, no. 2, pp. 683, Jan. 2016.

B. Walters, I. Kawrakow, D. W. O. Rogers, “DOSXYZnrc User’s Manual”, National Research Council of Canada, Ottawa, (Canada), 2023.

I. D. Nurhadi, R. Ramdani, F. Haryanto, Y. S. Perkasa, M. Sanjaya, “Analysis of Effect of Change Source to Surface Distance (SSD) and the Field Size to Distribution Dose Using Monte Carlo Method-EGSnrc”, Indonesian Journal of Physics, vol. 30, no. 1, pp. 14-17, Jul. 2019.

N. F. Nuzula, K. Adi, C. Anam, “Correction of 2D Isodose Curve on the Sloping Surface Using Tissue Air Ratio (TAR) Method”, Jurnal Sains dan Matematika, vol. 23, no. 3, pp. 65-72, 2015.

R. Fardela, A. M. Putri, I. Andriani, F, Diyona, R. Analia, D. Mardiansyah, “Analysis of OAR Dose in Radiotherapy for Sinastra Breast Cancer at Universitas Andalas Hospital”, Natural Science: Jurnal Penelitian Bidang IPA dan Pendidikan IPA, vol. 9, no. 2, pp. 112-123, Sep 2023.

D. Septhya, K. Rahayu, S. Rabbani, V. Fitria, Rahmaddeni, Y. Irawan, R. Hayami, “Implementation of Decision Tree Algorithm and Support Vector Machine for Lung Cancer Classification”, MALCOM: Indonesian Journal of Machine Learning and Computer Science, vol. 3, no. 1, pp. 15-19, Apr 2023.

Z. R. Utami, Margono, Y. Kusmiyati, "Hubungan Hamil Usia Dini dengan Kejadian BBLR di Kecamatan Karangmojo Kabupaten Gunungkidul Tahun 2018", B.S. thesis, Dept. of Midwifery, Poltekkes Kemenkes Yogyakarta, Yogyakarta, 2020

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MONTE CARLO ANALYSIS OF FETAL DOSE DISTRIBUTION IN PREGNANCY FOR DIFFERENT FETAL AGES, BEAM LOCATION, BEAM ENERGY, AND FIELD SIZES

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